منابع مشابه
Long-Term Fosfomycin-Tromethamine Oral Therapy for Difficult-To-Treat Chronic Bacterial Prostatitis.
This is a retrospective study of 15 difficult-to-treat (i.e., exhibiting previous failure, patient side effects, or resistance to ciprofloxacin and co-trimoxazole) chronic bacterial prostatitis infections (5 patients with multidrug-resistant Enterobacteriaceae [MDRE]) receiving fosfomycin-tromethamine at a dose of 3 g per 48 to 72 h for 6 weeks. After a median follow-up of 20 months, 7 patients...
متن کاملFosfomycin for Treatment of Prostatitis: New Tricks for Old Dogs.
Treatment options for prostatitis caused by multidrug-resistant gram-negative bacilli are limited. We report two cases cured with oral fosfomycin and provide a pharmacokinetic analysis of fosfomycin predose concentrations during treatment.
متن کاملFosfomycin kinetics after intravenous and oral administration to human volunteers.
The pharmacokinetics of fosfomycin, administered intravenously and orally at two different doses (20 and 40 mg/kg of body weight), was studied in seven volunteers. The elimination profile of this antibiotic, when administered intravenously, followed a two-compartment kinetic model, independent of dosage, giving an elimination half-life of 2.23 +/- 0.62 h and an average total volume of distribut...
متن کاملIs Fosfomycin a Potential Treatment Alternative for Multidrug-Resistant Gram-Negative Prostatitis?
B. J. Gardiner, A. A. Mahony, A. G. Ellis, N. Lawrentschuk, D. M. Bolton, P. T. Zeglinski, A. G. Frauman, and M. L. Grayson Department of Infectious Diseases and Department of Clinical Pharmacology, Austin Health, Heidelberg; Department of Surgery, Urology Unit, University of Melbourne; Ludwig Institute for Cancer Research, Austin Health, Heidelberg; and Department of Medicine, University of Me...
متن کاملRe: Is Fosfomycin a Potential Treatment Alternative for Multidrug-Resistant Gram-Negative Prostatitis?
BACKGROUND Multidrug-resistant gram-negative bacterial (MDR-GNB) infections of the prostate are an increasing problem worldwide, particularly complicating transrectal ultrasound (TRUS)-guided prostate biopsy. Fluoroquinolone-based regimens, once the mainstay of many protocols, are increasingly ineffective. Fosfomycin has reasonable in vitro and urinary activity (minimum inhibitory concentration...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2015
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/civ966